1.
Pharm Nanotechnol
; 9(1): 4, 2021.
Article
in English
| MEDLINE | ID: covidwho-1226933
2.
J Control Release
; 329: 758-761, 2021 01 10.
Article
in English
| MEDLINE | ID: covidwho-872217
ABSTRACT
Ivermectin is an FDA-approved broad-spectrum antiparasitic agent with demonstrated antiviral activity against a number of DNA and RNA viruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Despite this promise, the antiviral activity of ivermectin has not been consistently proven in vivo. While ivermectin's activity against SARS-CoV-2 is currently under investigation in patients, insufficient emphasis has been placed on formulation challenges. Here, we discuss challenges surrounding the use of ivermectin in the context of coronavirus disease-19 (COVID-19) and how novel formulations employing micro- and nanotechnologies may address these concerns.